For effective prevention and treatment of bleeds, the activity of both clotting factors needs to be restored. wilate\u00ae<\/sup> contains VWF and FVIII in a physiological 1:1 activity ratio to simultaneously restore the activity of both clotting factors, and facilitate simple and predictable dosing.2, 3<\/sup><\/p>\n Many people with von Willebrand disease also have low levels of FVIII, which also needs to be corrected in order to restore normal haemostasis1<\/sup><\/em><\/p>\n *Based on VWF and FVIII activity levels. FVIII, factor VIII; VWD, von Willebrand disease; VWF, von Willebrand factor.<\/p>\n Because of the predictable decay of VWF and FVIII in wilate\u00ae<\/sup>, coagulation activity can be monitored using either VWF or FVIII levels<\/em><\/p>\n *Based on von Willebrand factor and factor VIII activity levels. FVIII: factor VIII; VWF: von Willebrand factor.<\/p>\n Parallel decay of VWF:RCo and FVIII:C<\/em><\/p>\n FVIII:C: FVIII clotting activity; FVIII: factor VIII; VWF:Ag: VWF antigen; VWF:RCo: von Willebrand Ristocetin Cofactor; VWF: von Willebrand factor.<\/p>\n https:\/\/wilate.com\/ca\/wp-content\/uploads\/2022\/04\/Tutorial-II-willate.mp4#t=2<\/p>\n Each wilate\u00ae<\/sup> package contains a vial of wilate\u00ae<\/sup> powder, a vial of sterile water*, a nextaro\u00ae<\/sup> transfer device and an infusion set.<\/p>\n The wilate\u00ae<\/sup> powder dissolves rapidly and the nextaro\u00ae<\/sup> transfer device allows quick and easy mixing to help save time during administration.<\/p>\n wilate\u00ae<\/sup> may be infused at a rate of 2\u20133 mL per minute.<\/p>\n *Includes 0.1% Polysorbate 80.<\/p>\n Recommended dosing for wilate\u00ae<\/sup><\/p>\n *An initial dose of 50\u201380 IU\/kg may be required, especially in patients with VWD type 3. \u2020In some cases, such as in patients with gastrointestinal bleeds, higher doses may be necessary. FVIII:C: factor FVIII clotting activity for consistency; VWF:RCo: von Willebrand Ristocetin Cofactor.<\/p>\n **Treatment should be initiated under the supervision of a physician experienced in the treatment of coagulation disorders.<\/p>\n Surgery4<\/sup> An appropriate dose should be re-administered every 12-24 hours of treatment. The dose and duration of the treatment depend on the clinical status of the patient, the type and severity of bleeding, and both VWF:RCo and FVIII:C levels<\/em><\/p>\n On-demand treatment4<\/sup> Prophylaxis4<\/sup> wilate\u00ae<\/sup> is available in vials of 500 IU and 1000 IU. Each vial contains von Willebrand factor and factor VIII in a 1:1 ratio*.<\/p>\n *Based on von Willebrand factor and factor VIII activity levels.<\/p>\n Dosing In many people with von Willebrand disease, the activity of both von Willebrand factor (VWF) and factor VIII (FVIII) are reduced.1 For effective prevention and treatment of bleeds, the activity of both clotting factors needs to be restored. wilate\u00ae contains VWF and FVIII in a physiological 1:1 activity ratio to simultaneously restore the activity […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-6395","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nwilate\u00ae<\/sup> contains VWF and FVIII in a 1:1 ratio<\/h2>\n
\n<\/sup><\/em>wilate\u00ae<\/sup> contains VWF and FVIII in a 1:1 ratio*, similar to the ratio found in the blood of healthy individuals3<\/sup><\/em><\/p>\nThe balanced physiological 1:1 ratio<\/h2>\n
of wilate\u00ae<\/sup> facilitates dosing and monitoring*<\/em><\/h3>\n
\n<\/em>The ease of monitoring may help to ensure efficacy and tolerability of wilate\u00ae<\/sup> even after repeat dosing2<\/sup><\/em><\/p>\n![\"3_3@2x\"](\"https:\/\/wilate.com\/ca\/wp-content\/uploads\/sites\/5\/2022\/04\/3_3@2x.png\" "\\"3_3@2x\\"")
<\/p>\nThe balanced physiological 1:1 ratio<\/h2>\n
of wilate\u00ae<\/sup> facilitates dosing and monitoring<\/em><\/h3>\n
![\"3_4@2x\"](\"https:\/\/wilate.com\/ca\/wp-content\/uploads\/sites\/5\/2022\/06\/3_4@2x.png\" "\\"3_4@2x\\"")
<\/p>\n
\n<\/em>Simple dosing and monitoring using either VWF or FVIII levels<\/em><\/p>\nwilate\u00ae <\/sup>reconstitution<\/h2>\n
Dosing of wilate\u00ae<\/sup><\/h2>\n
\nVWF:RCo target level: \u226560 IU\/dL
\nFVIII:C target level: \u226540 IU\/dL<\/em><\/p>\n
\nBased on the clinical trial results, approximately 20\u201360 IU VWF:RCo\/kg are given to
\nachieve adequate hemostasis in case of bleeding.
\n<\/em><\/p>\n
\nFor long-term prophylaxis against bleeds in VWD patients, doses of 20\u201330 IU\/kg BW should be administered 1\u20133 times per week
\n<\/em><\/p>\nwilate\u00ae <\/sup>range of vial sizes<\/h2>\n
![\"Two](\"https:\/\/wilate.com\/ca\/wp-content\/uploads\/sites\/5\/2022\/05\/3_7-1-2_v2_tinified.png\" "\\"3_7-1-2_v2_tinified\\"")
<\/p>\nReferences<\/h4>\n
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